In the few clinical studies that have been conducted, it has been suggested that DIM may help prevent the growth of cancer cells — specifically breast cancer cells. DIM and Cancer. You can use Diindolylmethane (DIM) supplements for several health benefits that you can also avail from vegetables like Broccoli. Some people use DIM supplements to help them lose weight, and … DIM exerts these effects through numerous mechanisms, including by positively impacting estrogen metabolism and helping you remove xenoestrogens as discussed above. Curcumin can also limit weight gain. This is necessary because it will be hard to consume enough cruciferous vegetables in order to get just 10-30 mg of DIM daily. Due to a lack of research in humans, little is known about the long-term safety and side effects of DIM supplements. There are a number of positive effects of DIM in the body, but there has been a decided lack of research on this substance or its potential impact on long-term health. As stated in Clinical Naturopathy: In Practice, by regulating the levels of both testosterone and estrogen, it can help to reduce hormonal breakouts of acne, particularly those that occur around the time of menstruation in so many women, a condition known as cystic acne. It is being studied for its anticancer properties DIM is the most studied of all 13C metabolites and is being studied as a chemo-protective compound for certain types of cancer . You can use baking soda, chalk, or dishwashing liquid to loosen the stain before a wash. How to cut and dry rosemary? Another benefit of estrogen metabolism is weight loss. © 2020 Organic Information Services Pvt Ltd. All the information on this website is for education purpose only. Diindolylmethane, also known as DIM. As DIM supplements interact with estrogen levels, they may affect people with hormone-sensitive cancers or who are on hormone therapies. DIM is derived from cruciferous vegetables like Broccoli. In general, DIM’s ability to prevent large increases or decreases in estrogen can help with a number of issues, including acne, menopause symptoms, weight gain and even cancer. As a result, DIM supplements have been gaining popularity as a potential treatment for a variety of hormone-related conditions, including acne, menopause symptoms, prostate issues, and certain forms of cancer. Diindolylmethane Benefits May Help Prevent Cancer. Uses and potential benefits of DIM supplements DIM supplements are being studied for their protective effects against certain cancers. All rights reserved. While cruciferous vegetables are the primary food source of DIM, you would need to eat several servings every day to reap this compound’s benefits (1). Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, PMS Supplements: 7 Options for Mood Swings and Other Symptoms, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 7 Foods for Lowering Estrogen Levels in Men, Natural and Pharmaceutical Estrogen Blockers for Men, 12 Natural Ways to Boost Estrogen in Your Body, Our Favorite Healthy Finds: Organic Beauty Products for Acne-Prone Skin. A study carried out by the…. While the exact mechanism is unknown, indole-3-carbinol is thought to be partly responsible (4, 5, 6). Current human research doesn’t show DIM supplements to be toxic or have serious side effects. In supplement form, DIM is frequently prescribed for survivors of breast, uterine and colorectal cancer. Test-tube and animal studies likewise suggest that DIM helps fight prostate cancer. Our DIM hormone therapy supplement is derived from broccoli and pomegranate. But there’s no proof DIM actually works for endurance or sexual performance. A DIM supplement is a nutritional supplement composed of a phytochemical that our body naturally produces by breaking down a compound in our diet. Every now and then, I like to highlight a particular supplement that my audience may not be aware of, and go in-depth about its uses, benefits, and potential drawbacks. A 30-day study in 19 post-menopausal women with early-stage breast cancer found that taking 108 mg of DIM per day also resulted in beneficial changes in estrogen levels (9). If you’re looking for a quality DIM supplement, DrFormulas® DIM Plus BioPerine for Men & Womenprovides a convenient once-daily dose of all the DIM you need. DIM might even prevent cancer and acne. An advantage of supplementation with DIM over consumption of large amounts of raw cruciferous vegetables is avoidance of goitrogenic isothiocyanates. There have been rare instances when certain rice noodle brands may contain gluten. Last medically reviewed on July 22, 2020. Diindolylmethane (DIM) is a compound created when you digest cruciferous vegetables, such as broccoli or Brussels sprouts (1, 2). Before adding a DIM supplement to your diet, be sure to speak with your doctor about any risks or potential interactions. DIM stimulates more efficient metabolism for estrogen, meaning it helps regulate the ratio of healthy to less healthy estrogen. Some other possible side effects from this supplement include vomiting, headaches, nausea, rashes, and hyponatremia. It is commonly found in broccoli, and holds promise as being a molecule for anti-cancer effects and as an aromatase inhibitor. However, a study in 24 healthy people found that although DIM doses of up to 200 mg were well tolerated and didn’t cause side effects, one person experienced nausea, headache, and vomiting after taking a 300-mg dose, suggesting that higher doses may be associated with adverse side effects (15). Furthermore, DIM supplements may stimulate fat breakdown and inhibit fat cell formation. DrFormulas® DIM Plus Bioperine Supplement is specially formulated to support hormone balance. But this does not mean that DIM is always safe in supplemental form. The scientific community continues to reveal the numerous benefits of this supplement and the findings so far are positive and promising. But the precise reasons behind this are less known. Health benefits of apple cider vinegar include its ability to regulate blood sugar levels, boost weight loss, improve skin & gut health, & lower cholesterol levels.Read more! Other uses of DIM supplements, such as weight loss and acne treatment, have not been studied in humans. Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss — although no human research currently supports this effect. This supplement helps to free up the bound testosterone, promote lean muscle mass building, support weight management, enhance athletic … 2 Keep in mind since pure DIM must be provided in an absorption-enhancing formulation, the dose for DIM specifies the weight of the Absorbable Formulation, which is only one forth DIM. Here is the step-by-step method to use lemongrass. Diindolylmethane (DIM) is a versatile nutraceutical for which I find many uses in my practice. In human research, doses typically range from 108–900 mg per day — though these studies were only related to treatments for cancer and prostate enlargement (8, 9, 14). Our website services, content, and products are for informational purposes only. Another DIM supplement benefit is it may help treat symptoms of HPV (human papilloma virus). Photo Credit: Shutterstock. In addition to Diindolylmethane, they also have a chemical called indole-3-carbinol. As a supplement, Diindolylmethane comes with many benefits for the human body. Our articles are evidence-based and contain scientific references, fact-checked by experts. Test-tube and animal studies indicate that DIM protects against ovarian, prostate, and colon cancers as well. John Staughton is a traveling writer, editor, publisher and photographer with English and Integrative Biology degrees from the University of Illinois in Champaign-Urbana (USA). DIM and Hormonal Acne. The same can be said about vegetables that contain Diindolylmethane. Similarly, some studies have found that diindolylmethane can also control the levels of testosterone in the body, by preventing the transition of testosterone into estrogen when an excess of aromatase enzyme is present, which places this supplement in the realm of an aromatase inhibitor. Negative interactions with diuretic medications and liver medications have also been reported, as DIM may speed up how quickly medications are broken down in the liver. Before taking these supplements, get dosage guidance from your healthcare provider. DIM exerts an anti-fibrosis, anti-tumor, antioxidant, immunomodulatory, detoxification and anti-inflammation effects on liver protection. An average diet will likely contain less than 25 mg of diindolylmethane per day, yet some supplements may offer more than 500mg in a daily dose. Therefore, it’s best to talk to your healthcare provider to obtain personalized dosage recommendations based on your intended use. A DIM supplement could help you shed those pesky pounds! DIM helps in weight loss – Most women struggling with seemingly impossible weight loss is due to imbalanced estrogen. The antioxidant and anti-inflammatory properties of turmeric, mainly due to its compound curcumin, is responsible for weight loss. Average rating 5.0 out of 5.0 based on 2 user(s). The therapeutic dose of DIM that most experts recommend is 100 to 200 mg each day. While estrogen is the hormone typically associated with females, it is also present in males, and the balance of testosterone and estrogen in the body can have noticeable side effects when out of balance. Trying to choose a supplement to combat your PMS or PMDD? Diindolylmethane supplements—DIM for short—have been credited with combatting breakouts and other period problems. What helps set it apart is the other unique benefits it provides. DIM supplements have not been shown to cause serious side effects, though more safety research is needed. We’ll go over 7 science-backed PMS supplements that may provide relief for both physical and…, Men who are experiencing low testosterone, or “low T,” often have elevated levels of the hormone estrogen. Diindolylmethane is used for preventing breast, uterine, and colorectal cancer. Also, the DIM supplement additionally influences testosterone, a hormone that is connected to zits. No matter DIM’s effectiveness, it’s always good to eat more cruciferous veggies. First, you will have to discard the tough outer leaves of the lemongrass stalks by peeling them away with your fingers. Some of the benefits being researched include a positive impact on cancerous cell growth, reduction in acne, prevention of an enlarged prostate, … DIM supplement benefits include relieving hot flashes, night sweats and other symptoms of hormonal imbalance. While some show severe symptoms, many remain asymptomatic. Health benefits of hibiscus tea include its ability to control hypertension & reduce high blood pressure, lower blood sugar levels, & improve liver health. DIM supplements resulted in a significantly improved ratio of two types of estrogen — 2-hydroxyestrone and 16-hydrozyestrone (8). Low estrogen is typically seen in younger women and women approaching menopause. Rash, nausea, vomiting, headache, arthralgia and hot flashes have been reported. How to Use DIM. DIM was found to be more stable and more suitable for use in supplements. Diindolylmethane (DIM) is the compound in cruciferous vegetables that makes experts advise people at risk for breast cancer to eat more cabbage and broccoli as a preventive measure. While it’s predominately lauded for its hormone support benefits, DIM has been picking up steam for its metabolic benefits too. For this, you will have to look out for green stems. DIM can mitigate the level of estrogen in the body by stimulating the breakdown of estrogen in beneficial metabolites. DIM, short for diindolylmethane, is a hormone balancer. To date, research on the health effects of diindolylmethane is fairly limited. Due to limited research, proper dosages for DIM are unknown. Benefits of DIM. When NOT to Use DIM. While testosterone is known as a male hormone, it is also produced in a woman’s body, but instead, it converts into estrogen. As a result, people looking to treat a specific condition like acne or prostate issues may seek a concentrated dose in the form of a DIM supplement. Although DIM is not suitable for everyone, DIM appears to have benefits for both men and women, and DIM side effects are minimal. As mentioned above, increased levels of DIM in your system can inhibit the conversion of testosterone to estrogen in men. Learn how to identify the symptoms, what causes it, and more. Estrogen Metabolism Benefits of DIM Plus Estrogen metabolism can have a positive effect on acne and other skin issues. The primary natural source of DIM is the digestion of cruciferous vegetables. This supplement has amazing cancer-fighting properties. He co-founded the literary journal, Sheriff Nottingham, and now serves as the Content Director for Stain’d Arts, a non-profit based in Denver, Colorado. DIM supplements are being studied for their protective effects against certain cancers. What’s more, it contains an optimal do… However, in a 6-month study in 551 women with cervical abnormalities, taking 150 mg of DIM per day had no effect on cervical cell changes (3, 13). Keep in mind that human studies are needed. A yearlong study gave 130 women with breast cancer on tamoxifen therapy either a placebo or 150 mg of DIM twice a day. However, it is not a plant estrogen or an estrogen mimic, like soy isoflavones. DIM supplements are attracting a lot of attention recently as they have been touted to have properties that could minimize the risk of cancer. Uses and potential benefits of DIM supplements, Cruciferous Vegetables: Health Benefits and Recipes. DIM has been shown to provide potential protection against hormone-dependent cancers such as breast, uterus and cervical cancer. On average 10-20 percent of I3C is metabolized to DIM. You can continue to get DIM through eating cruciferous vegetables and letting your body do the natural process to produce DIM; but be careful how you cook these vegetables. It’s also concentrated and sold as a supplement. The entire list of reference links is also provided at the bottom of the article. Now a new…, COVID-19 shows a wide range of manifestations among those affected. The DIM supplement helps support the liver detoxification process, improves the procedure of estrogen breakdown. Thus, you should talk to your healthcare provider before taking DIM supplements. Those given DIM experienced significant improvements in prostate health, as well as PIN (14). ✓ Evidence Based. DIM supplements may: Suppress tumor growth; Aid fat loss; Reduce hormonal acne; Balance estrogen levels; Protect against some cancerous tumors; Prevent or treat thyroid disorders How to Use DIM for Hormonal Acne. DIM Supplement Benefits DIM is most effective in helping maintain hormonal balance, especially between estrogen and testosterone in both men and women. Here's what you need to know about how they work and if … DIM is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, and kale. It is also commonly used as preventative medicine for cancer by non-traditional healers, due to its purported anti-cancer effects. Having too much estrogen in the body can increase the risk of breast cancer, along with cervical cancer and ovarian cancer. The study divided the women into two groups; the first group was to take a 150g DIM supplement twice daily, and the second group was to take a placebo. Read on to learn more about the benefits of supplementing with DIM, as well as the specific effects of using DIM Plus. While these benefits are promising, overall research on DIM’s effectiveness and long-term safety in humans is limited. Your hormones underlie many basic processes in your body. by John Staughton (BASc, BFA) When you eat cruciferous vegetables, your stomach acid breaks down a compound called indole-3-carbinol to produce a new compound called DIM (3). BENEFITS FOR MEN – LEAN MUSCLE MASS BUILDING & MORE* DIM acts as an Estrogen Blocker inhibits the Aromatase enzyme that converts testosterone into estrogen and helps prevent estrogen dominance, providing natural testosterone support. Resources and Additional Reading: It is naturally obtained via dietary consumption of cruciferous vegetables. Diindolylmethane, more commonly abbreviated to DIM, is a beneficial supplement that can help our body regulate itself more efficiently. Ginger also helps boost bone health, strengthen the immune system, and increase appetite. Due to insufficient evidence, dosage information for DIM is lacking. Dates are sweet fruits of the date palm tree. Some of the benefits being researched include a positive impact on cancerous cell growth, reduction in acne, prevention of an enlarged prostate, and treatment of the premenstrual syndrome. Along with eating cruciferous vegetables each day as a part of your Male Fertility Diet, consider a DIM supplement. If you suffer from hormone-related conditions, the addition of more estrogen-like compounds could exacerbate the problems, such as in the case of endometriosis, ovarian cancer or uterine fibroids. Benefits are a lot, a few proved with research and others are still being studied. Kid social media influencers are promoting junk food and sugar-filled beverages in their YouTube videos, and they are garnering more than a billion views,…, We know that music, particularly musical training can improve the functioning of the brain. In fact, it may help combat prostatic intraepithelial neoplasia (PIN), a condition that’s characterized by prostate cell growth and considered to be a precursor to prostate cancer (14). Traditionally used as an add-on to prevent the recurrence of a rare respiratory disease, this compound is now being investigated as a cancer-preventing agent. The powerful health benefits of dates include providing an energy boost, increasing iron in the body, and aiding digestion.Â. DIM Supplement normally comes in capsules, sometimes in combination with other supplements to optimize the desired outcome. Always use scissors or pruning shears to make clean cuts. Cut rosemary on the new growth. Anti-cancer Properties: Diindolylmethane can prevent and stop certain cancers from developing by controlling estrogen levels. Word is getting out, and DIM has started picking up steam as a supplement of choice to deal with a variety of issues such as acne, PMS, mood swings, fibroids, menopause symptoms, and even things like man boobs. Organic Facts may receive a portion of revenues if you click on the sponsored ads and links by Google, Ezoic, or the Amazon Affiliate program. In preliminary research, some scientists have found that diindolylmeth… One study analyzes the effect of DIM on 130 women with breast cancer over 12 months. As mentioned above, the primary natural sources of DIM (diindolylmethane) is cruciferous vegetables, such as: There has been no clear evidence that using DIM supplements is dangerous or has an implicit risk, but certain side effects have been reported when the supplement is not taken in moderation, or in conjunction with other medications. DIM has been the topic of recent discussions surrounding hormonal health and your menstrual cycle. This article provides a comprehensive overview of DIM supplements, including their benefits and side effects. More specifically, DIM (diindolylmethane) is produced when we eat cruciferous vegetables, which are often recommended in a healthy diet. In one study in mice on a high fat diet, 23 mg of DIM per pound (50 mg per kg) of body weight significantly reduced the formation of new fat cells (19). These compounds compete with iodine for binding in the thyroid, potentially contributing to hypothyroidism. © 2005-2020 Healthline Media a Red Ventures Company. The excess can be blotted out gently using a tissue. Still, more human research is necessary (15). Read more! Diindolylmethane is purported to produce changes in estrogen metabolism, a biological process thought to influence the development of certain hormone-dependent cancers such as breast cancer. DIM may have anti-cancer effects. Therefore, a recommended dose from a supplement would look more like 100 to … DIM is a compound your body creates when you eat cruciferous vegetables. It also prevents prostate cancer and BPH. Consult a medical practitioner for health problems. Benefits of calamansi juice include bleaching the skin, detoxifying the body, aiding in weight loss & managing diabetes. DIM can mitigate the level of estrogen in the body by stimulating the breakdown of estrogen in beneficial metabolites. Taking DIM can help with menopause symptoms like weight gain, hot flashes, mood swings, etc. Such individuals should steer clear of DIM supplements unless under the supervision of a medical professional. Users have experienced an increase in their sex drive and libido, which isn’t common in other DIM supplements. As it affects estrogen levels, DIM may help treat a variety of conditions, including hormone-sensitive cancers and prostate issues. Some websites say DIM can even help with sexual function in both men and women. DIM supplements contain diindolymethane, which is found in cruciferous vegetables like broccoli and cabbage. DIM supplements are purported to aid other hormone-related conditions. This includes cervical dysplasia and respiratory papillomatosis. It may also help reduce the effects of a stronger form called 16 alpha-hydroxyestrone, which has been linked to weight gain and an increased risk of some cancers, including breast and uterine cancer (1, 7). On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve. It may help to support acne relief, healthy menopause, and prostate health. DIM ameliorates experimental liver fibrosis induced by thioacetamide in mice [ 35 ]. Taking DIM, together with low-calorie calorie diet & exercise can make weight loss easier. There are several key health benefits of DIM supplementation that mostly tie back to its ability to reduce and block the accumulation of harmful estrogens in the body; especially in breast and prostate tissue. If you take a DIM supplement, you’re bypassing these steps but can still take full advantage of the health benefits of DIM. Your body produces diindolylmethane, or DIM, from substances naturally found in cruciferous vegetables. For women, an excess of estrogen (commonly known as “estrogen dominance”) can result in unpleasant menstrual symptoms, including heavy periods, shorter cycles, and more severe physiological side effects to the mood and energy levels. Children, pregnant women, and those who are breastfeeding can consume small amounts of this supplement, but not much more than the daily intake one would get from food, which could be in the range of 25-50 mg. Specifically, DIM may stimulate the production of a less potent, more beneficial form of estrogen known as 2-hydroxyestrone (1). Healthline Media does not provide medical advice, diagnosis, or treatment. › Supplement Ingredients › DIM Health Benefits And Uses Of DIM. If yes, please share your email to subscribe. DIM supplements is commonly taken in doses of 100 mg to 200 mg. However, it is not a plant estrogen or an estrogen mimic, like soy isoflavones. It will likewise urge estrogen to separate into the ‘great’ metabolites as opposed to the ‘terrible’ ones. They’re also used to help prevent prostate enlargement, treat acne, aid weight loss, and reduce premenstrual syndrome (PMS) and menopause symptoms. Diindolylmethane, or DIM, is a natural chemical formed in your digestive tract from a compound called glucobrassicin, which is contained in cruciferous vegetables such as broccoli, cauliflower and cabbage. Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol (I3C), found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. We are still learning more about the powerful effects of this plant-based nutrient, but here are a few of the science-backed benefits. Intriguingly, observational studies associate high cruciferous vegetable intake with a reduced risk of certain cancers, including breast and prostate cancer. How to get oil out of clothes? This article reviews 12 actions you can take to help your hormones function optimally. We source information from studies, clinical trial findings, and meta-analyses published in peer-reviewed journals. It can also be a helpful tool for those struggling to reduce body fat in specific areas of the body. Benefits of DIM Supplement. Take DIM with Milk Thistle for Liver detox & Endometriosis: Taking DIM with another supplement called milk thistle has been shown to reduce the severity of endometriosis. Share: Hormone Balance DIM Background and Benefits. Estrogen dominance can play a role in the development of acne because it can lead to oily skin and clogged pores. Limited studies suggest that DIM supplements may help reduce prostate enlargement and protect against certain cancers. Do you want the best of science-backed health & nutrition information in your inbox? DIM is a compound your body makes from cruciferous vegetables. DIM is an abbreviation for 3,3′-diindolylmethane, which is composed of a methane group with two indole groups attached to it. not the BioResponse version) is not absorbed very well (or at least this is claimed by BioResponse). DIM is particularly interesting to researchers because of its estrogen-like qualities, along with its paradoxical abilities to control an excessive amount of estrogen production. Are gluten-free as they have been reported least this is necessary ( 15 ), more beneficial of! 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